Rapid Communication: relative effect of urinary calcium and oxalate on saturation of calcium oxalate.
نویسندگان
چکیده
BACKGROUND The study compared the effect of urinary calcium with that of oxalate on urinary saturation [relative saturation ratio (RSR)] of calcium oxalate. METHODS A retrospective data analysis was conducted on urinary stone risk analysis from 667 patients with predominantly calcium oxalate stones. Urinary RSR of calcium oxalate was individually calculated using Equil 2. A "theoretical" curve of the relationship between urinary RSR of calcium oxalate and concentration of calcium or oxalate was obtained at two stability constants for calcium oxalate complex, while varying calcium or oxalate and using group mean values for urinary constituents. RESULTS At the stability constant of 7.07 x 10(3), the increase in RSR of calcium oxalate was less marked with calcium than with oxalate. However, at the stability constant of 2.746 x 10(3) from the Equil 2 that is considered the "gold standard," calcium and oxalate were equally effective in increasing RSR of calcium oxalate. The above theoretical curves (relating RSR with calcium or oxalate) were closely approximated by the actual curves constructed with data from individual urine samples. Urinary saturation of calcium oxalate was equally dependent on urinary concentrations of calcium and oxalate (r= 0.75 unadjusted and 0.57 adjusted for variables, and P < 0.0001 for calcium; r= 0.73 unadjusted and 0.60 adjusted, P <0.0001 for oxalate). CONCLUSION Among calcium oxalate stone-formers, urinary calcium is equally effective as urinary oxalate in increasing RSR of calcium oxalate.
منابع مشابه
Different dietary calcium intake and relative supersaturation of calcium oxalate in the urine of patients forming renal stones.
1. Dietary calcium restriction, an efficient practice in reducing urinary calcium excretion, has been reported to induce either an increase or no change in oxalate excretion, questioning its use in hypercalciuric stone-forming patients. In addition, calcium restriction has been previously demonstrated to induce other urinary changes which might influence the relative supersaturation of calcium ...
متن کاملمطالعهی شیمیایی اثر درمانی عصاره‌ی آبی گیاه خارشتر بر تشکیل و انحلال سنگ‌های کلیوی کلسیم اگزالات
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متن کاملTitle Circadian rhythms of urinary saturation levels of calcium oxalate and calcium phosphate in normal male individuals
متن کامل
The relative effects of supplemental dietary calcium and oxalate on urine composition and calcium oxalate relative supersaturation in healthy adult dogs.
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متن کاملCircadian rhythms of urinary saturation levels of calcium oxalate and calcium phosphate in normal male individuals.
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ورودعنوان ژورنال:
- Kidney international
دوره 66 5 شماره
صفحات -
تاریخ انتشار 2004